Sid O’Bryant, Ph.D.



National Academy of Neuropsychology


Sid O’Bryant, Ph.D.

University of North Texas Health Science Center

Sid O’Bryant’s research has focused largely on diagnostics of Alzheimer’s disease (AD) and mild cognitive impairment using both neuropsychological and proteomic methods.

O’Bryant has been working on the identification of a blood test that can be utilized by primary care providers to determine which elderly patients should be referred for specialty assessment for possible AD. In 2010 O’Bryant and colleagues published a blood-based proteomic profile that yielded excellent diagnostic accuracy in detecting AD, and in 2011 they were the first group to cross-validate such an approach across independent cohorts. O’Bryant and colleagues refined the algorithm and validated it on an assay platform that is readily available and can be implemented in most laboratory settings. They have translated their method back to the bench-top, validating the approach as highly accurate at detecting AD pathology in human and mouse brain tissue as well as mouse peripheral serum.

His body of research is moving the field toward an algorithm that can yield excellent diagnostic accuracy at detecting even very mild AD, thereby moving closer to the possibility of a point-of-care device.

O’Bryant maintains a very active role in raising awareness of Alzheimer’s disease science across all levels including features on English- and Spanish-speaking radio and television; newspaper and magazine articles; outreach to local agencies, particularly those working with underserved populations; and presentations at national and international scientific organizations.

O’Bryant completed his post-doctoral fellowship in neuropsychology at New Orleans VA Medical Center in 2005, and he earned his Ph.D. in clinical psychology from the State University of New York at Albany in 2004.

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